Pfizer’s Rare Disease Research Unit (RDRU) is dedicated to the development of novel therapeutics for orphan diseases. The recent and rapid emergence of large databases of genotype/phenotype data has led to many new and exciting opportunities for human genetics to advance rare disease drug development projects. The RDRU Integrative Biology team is searching for a computational geneticist with a deep passion for extending our understanding of the genetics of rare disease and translating these insights into novel therapeutics. As a member of our Integrative Biology team located in Cambridge, Massachusetts, you will be responsible for designing and delivering analyses that incorporate both proprietary and public genetics and other ‘omics datasets for target discovery and target validation. You will work with laboratory biologists, computational biologists, geneticists, and statisticians within the RDRU and across the broader Pfizer community in a highly collaborative environment to deliver impactful and actionable insights from human genetics. A successful candidate will also be comfortable working with external collaborators from industry and academia to advance our understanding of the genetics of rare disease.
Apply principles of human medical and population genetics to inform project teams of therapeutic opportunities and potential safety liabilities of targets relevant to key strategic areas in the RDRU
Provide quantitative genetics expertise and understanding of functional genomics to conduct reproducible analyses to aid in the identification of novel therapeutic targets, to validate therapeutic hypotheses and to forward mechanistic understanding of disease pathogenesis and causal pathways
Serve as genetics lead for the RDRU by collaborating with internal partners in statistics, bioinformatics, computational biology and research project leaders to drive quantitative genetic data analysis and data integration and to incorporate novel or emerging genetic methodology
Stay current with genetics literature and conferences to identify and incorporate new discoveries of potential interest to the research unit
Manage, develop and maintain internal and external collaborative projects to specified timelines and milestones
Synthesize and clearly communicate study findings and analyses with to a diverse audience of internal partners, leadership, administration, and collaborators
Manage, support and promote relationships with the external community that can add value to target selection and validation for the RDRU
Background in biological and/or quantitative sciences; PhD in genetics, statistical genetics, or a related field with 0-3 years relevant experience
Sound statistical and quantitative skills with knowledge of epidemiological principles and population-based research.
Familiarity with WGS/WES analysis, variant annotation and key genetics databases such as gnomAD
Proficiency in programming, scripting, querying and statistical analysis languages such as R, Python, Perl, SQL
Proficiency in standard methods for reproducible research such as Jupyter notebooks or Rmarkdown
Deep desire to understand biological and pathological processes that lead to human disease
Excellent communication, interpersonal, and presentation skills
Background in human biology/medicine with some knowledge of pathophysiology in the areas of neurologic, hematologic or metabolic disease is highly preferred
Understanding of methodology specific to the genetics of rare disease
Track record of innovative and impactful research in genetics including peer-reviewed publications
Experience analyzing large genetics datasets and integrating additional data types to further clinical and biological understanding
Experience analyzing data from at least one other ‘omics technology such as transcriptomics, proteomics, lipidomics, metabolomics or epigenomics
Ability to multi-task and prioritize amongst competing time-sensitive projects
Strong desire to continually learn new skills
Ability to perform mathematical calculations, ability to perform complex data analysis
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EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.
Other Job Details
Eligible for Employee Referral Bonus
Internal Number: 4762966
About Pfizer Inc.
Pfizer is a leading research-based biopharmaceutical company. We apply science and our global resources to deliver innovative therapies that extend and significantly improve lives. We make medicines and vaccines that help people when they are sick and prevent them from getting sick in the first place, as well as some of the world’s best-known consumer healthcare brands. Every day, our colleagues work in developed and emerging markets to treat, cure and eradicate life-threatening conditions and challenge some of the most feared diseases of our time. Pfizer also collaborates with healthcare providers, governments and local communities to support and expand access to reliable, affordable healthcare around the world. For more than 150 years, Pfizer has worked to make a difference for all who rely on us. To learn more, visit www.pfizer.com. For additional information on our guidelines, please visit http://www.pfizer.com/community-guidelines